Drug interactions
Amikacin + Streptozocin
Severity: Major
Amikacin and Streptozocin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptozocin commonly causes dose-related renal tubular toxicity. Adding amikacin, which is also nephrotoxic, increases the likelihood and severity of kidney injury.
What this interaction means in plain words
Amikacin and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity affecting the proximal renal tubule.
What to do
Avoid concurrent use when possible. If necessary, monitor serum creatinine, urinalysis and electrolytes frequently and adjust the aminoglycoside by levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Streptozocin?
MediHelp rates the interaction as major. Amikacin and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Streptozocin commonly causes dose-related renal tubular toxicity. Adding amikacin, which is also nephrotoxic, increases the likelihood and severity of kidney injury.
How serious is the interaction between Amikacin and Streptozocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible. If necessary, monitor serum creatinine, urinalysis and electrolytes frequently and adjust the aminoglycoside by levels.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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