Drug interactions
Amikacin + Tenofovir df
Severity: Moderate
Amikacin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the renal tubules, and tenofovir is renally eliminated, so reduced kidney function may raise tenofovir exposure. Concurrent use increases the risk of acute kidney injury and tubular dysfunction.
What this interaction means in plain words
Amikacin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive proximal tubular nephrotoxicity, with reduced renal clearance of tenofovir when function falls.
What to do
Monitor serum creatinine, phosphate and urinalysis regularly, and consider an alternative to tenofovir DF or a non-nephrotoxic antibacterial if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Tenofovir df?
MediHelp rates the interaction as moderate. Amikacin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the renal tubules, and tenofovir is renally eliminated, so reduced kidney function may raise tenofovir exposure. Concurrent use increases the risk of acute kidney injury and tubular dysfunction.
How serious is the interaction between Amikacin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urinalysis regularly, and consider an alternative to tenofovir DF or a non-nephrotoxic antibacterial if renal function declines.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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