Drug interactions
Amikacin + Ticarcillin
Severity: Moderate
Amikacin and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin can bind aminoglycosides in vitro and lower their activity, and this inactivation is most relevant in patients with renal failure where drug levels persist. Amikacin concentrations may be reduced, potentially causing therapeutic failure.
What this interaction means in plain words
Amikacin and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Physicochemical inactivation of amikacin by ticarcillin through chemical binding, which is more pronounced in renal impairment.
What to do
Administer the two drugs at separate sites and times, never in the same syringe or infusion. Monitor amikacin serum levels in patients with renal impairment and adjust the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ticarcillin?
MediHelp rates the interaction as moderate. Amikacin and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticarcillin can bind aminoglycosides in vitro and lower their activity, and this inactivation is most relevant in patients with renal failure where drug levels persist. Amikacin concentrations may be reduced, potentially causing therapeutic failure.
How serious is the interaction between Amikacin and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Administer the two drugs at separate sites and times, never in the same syringe or infusion. Monitor amikacin serum levels in patients with renal impairment and adjust the dose.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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