Drug interactions
Amikacin + Trimagnesium
Severity: Moderate
Amikacin and Trimagnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium and aminoglycosides both depress neuromuscular transmission. Together they may cause muscle weakness and, rarely, respiratory paralysis, mainly with parenteral or high-dose magnesium or impaired renal function.
What this interaction means in plain words
Amikacin and Trimagnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive neuromuscular blockade through reduced acetylcholine release.
What to do
Monitor for weakness and respiratory function, and check serum magnesium and renal function. Avoid unnecessary magnesium during aminoglycoside therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Trimagnesium?
MediHelp rates the interaction as moderate. Amikacin and Trimagnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium and aminoglycosides both depress neuromuscular transmission. Together they may cause muscle weakness and, rarely, respiratory paralysis, mainly with parenteral or high-dose magnesium or impaired renal function.
How serious is the interaction between Amikacin and Trimagnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for weakness and respiratory function, and check serum magnesium and renal function. Avoid unnecessary magnesium during aminoglycoside therapy.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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