Drug interactions
Amiloride + Enoxaparin
Severity: Moderate
Amiloride and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin can suppress aldosterone production and lead to hyperkalemia, adding to amiloride's potassium-sparing action. Risk is higher with renal impairment, diabetes or longer treatment.
What this interaction means in plain words
Amiloride and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone secretion combined with amiloride's ENaC blockade reduces potassium excretion.
What to do
Monitor serum potassium, especially in prolonged therapy or reduced renal function. Stop amiloride if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Amiloride with Enoxaparin?
MediHelp rates the interaction as moderate. Amiloride and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enoxaparin can suppress aldosterone production and lead to hyperkalemia, adding to amiloride's potassium-sparing action. Risk is higher with renal impairment, diabetes or longer treatment.
How serious is the interaction between Amiloride and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially in prolonged therapy or reduced renal function. Stop amiloride if hyperkalemia develops.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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