Drug reference
enoxaparin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Thrombotics)
Mechanism of action
LMWH; antithrombotic that inhibits factor Xa by increasing inhibition rate of clotting proteases that are activated by antithrombin III Generally does not increase PT or PTT
Common side effects
- Anemia
- Thrombocytopenia
- Fever
- Hemorrhage
- Elevation of serum aminotransferases
- Local site reactions
Boxed warnings
- Epidural or spinal hematomas may occur in patients anticoagulated with low-molecular-weight heparin (LMWH) or heparinoids who receive neuraxial (epidural/spinal) anesthesia or spinal puncture These hematomas may result in long-term or permanent paralysis Patients should be frequently monitored for signs and symptoms of neurologic impairment (eg, tingling, numbness, muscular weakness) If neurologic compromise is noted, urgent treatment is necessary Physicians should consider the benefits versus risk before neuraxial intervention in patients anticoagulated or to be anticoagulated fo…
Contraindications
- Active major bleeding, thrombocytopenia with antiplatelet antibody in presence of enoxaparin or heparin History of heparin-induced thrombocytopenia (HIT) within past 100 days or in presence of circulating antibodies Hypersensitivity to enoxaparin, heparin, pork products, benzyl alcohol (multi…
Known interactions (14)
- enoxaparin + mifepristone Contraindicated
- abciximab + enoxaparin Major
- bazedoxifene-conjugated estrogens + enoxaparin Major
- cilostazol + enoxaparin Major
- enoxaparin + eptifibatide Major
- enoxaparin + ethinyl estradiol-drospirenone Major
- enoxaparin + ethinyl estradiol-levonorgestrel Major
- enoxaparin + ticlopidine Major
- enoxaparin + tirofiban Major
- anagrelide + enoxaparin Moderate
- desogestrel-ethinyl estradiol + enoxaparin Moderate
- dipyridamole + enoxaparin Moderate
- enoxaparin + estradiol Moderate
- enoxaparin + piperacillin Moderate
Related conditions
Frequently asked questions
What drug class is enoxaparin?
enoxaparin belongs to: Cardiovascular.
How does enoxaparin work?
LMWH; antithrombotic that inhibits factor Xa by increasing inhibition rate of clotting proteases that are activated by antithrombin III Generally does not increase PT or PTT
What are the common side effects of enoxaparin?
Anemia, Thrombocytopenia, Fever, Hemorrhage, Elevation of serum aminotransferases, Local site reactions
Which drugs interact with enoxaparin?
mifepristone, abciximab, bazedoxifene-conjugated estrogens, cilostazol, eptifibatide, ethinyl estradiol-drospirenone, ethinyl estradiol-levonorgestrel, ticlopidine, tirofiban, anagrelide, desogestrel-ethinyl estradiol, dipyridamole, estradiol, piperacillin
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