Drug interactions
Amiloride + Epoprostenol
Severity: Minor
Amiloride and Epoprostenol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower blood pressure, so combined use may produce additive hypotension. Epoprostenol is a potent vasodilator and amiloride may add volume depletion or reduced vascular tone.
What this interaction means in plain words
Amiloride and Epoprostenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive pharmacodynamic blood pressure lowering from vasodilation and diuresis.
What to do
Monitor blood pressure when starting or adjusting either drug, particularly during epoprostenol dose titration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Amiloride with Epoprostenol?
MediHelp rates the interaction as minor. Amiloride and Epoprostenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents can lower blood pressure, so combined use may produce additive hypotension. Epoprostenol is a potent vasodilator and amiloride may add volume depletion or reduced vascular tone.
How serious is the interaction between Amiloride and Epoprostenol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or adjusting either drug, particularly during epoprostenol dose titration.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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