Drug interactions
Amlodipine-benazepril + Epoprostenol
Severity: Moderate
Amlodipine-benazepril and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent pulmonary and systemic vasodilator, and its combination with antihypertensives can produce additive hypotension. Dizziness, syncope or reduced organ perfusion may occur.
What this interaction means in plain words
Amlodipine-benazepril and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive pharmacodynamic vasodilatory and hypotensive effects.
What to do
Monitor blood pressure during epoprostenol initiation and dose changes. Reduce antihypertensive doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Epoprostenol
Frequently asked questions
Can I take Amlodipine-benazepril with Epoprostenol?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent pulmonary and systemic vasodilator, and its combination with antihypertensives can produce additive hypotension. Dizziness, syncope or reduced organ perfusion may occur.
How serious is the interaction between Amlodipine-benazepril and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during epoprostenol initiation and dose changes. Reduce antihypertensive doses if hypotension develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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