Drug interactions
Amiloride + Eprosartan-hydrochlorothiazide
Severity: Major
Amiloride and Eprosartan-hydrochlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan and amiloride both raise serum potassium, while hydrochlorothiazide lowers it, so the net effect is unpredictable. Hyperkalemia can occur, especially in renal impairment, diabetes or older patients.
What this interaction means in plain words
Amiloride and Eprosartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade reduces aldosterone-mediated potassium excretion and amiloride blocks the epithelial sodium channel, while thiazide causes potassium loss.
What to do
Check serum potassium and renal function within the first week or so of combined use and periodically thereafter; avoid potassium supplements and stop amiloride if hyperkalemia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as major. Amiloride and Eprosartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eprosartan and amiloride both raise serum potassium, while hydrochlorothiazide lowers it, so the net effect is unpredictable. Hyperkalemia can occur, especially in renal impairment, diabetes or older patients.
How serious is the interaction between Amiloride and Eprosartan-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function within the first week or so of combined use and periodically thereafter; avoid potassium supplements and stop amiloride if hyperkalemia develops.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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