Drug reference
eprosartan-hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Eprosartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors, causing a lowering in blood pressure; blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II. HCT: inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water and of sodium, potassium, and hydrogen ions
Common side effects
- Decreased neutrophil count
- Back pain
- Increased BUN
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to eprosartan, hydrochlorothiazide, or sulfonamides Pregnancy (2nd/3rd trimesters): Significant risk of fetal/neonatal morbidity and mortality Anuria Do not coadminister with aliskiren in patients with diabetes mellitus
Known interactions (1)
Related conditions
Frequently asked questions
What drug class is eprosartan-hydrochlorothiazide?
eprosartan-hydrochlorothiazide belongs to: Cardiovascular.
How does eprosartan-hydrochlorothiazide work?
Eprosartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors, causing a lowering in blood pressure; blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II. HCT: inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water and of sodium, potassium, and hydrogen ions
What are the common side effects of eprosartan-hydrochlorothiazide?
Decreased neutrophil count, Back pain, Increased BUN
Which drugs interact with eprosartan-hydrochlorothiazide?
isocarboxazid
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.