Drug interactions
Amiloride + Erdafitinib
Severity: Moderate
Amiloride and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits the renal transporter OCT2, which contributes to the tubular secretion of amiloride. This may increase amiloride exposure and the risk of dose-related adverse effects such as hyperkalemia.
What this interaction means in plain words
Amiloride and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib inhibits OCT2-mediated renal tubular secretion of amiloride, reducing its clearance.
What to do
Monitor serum potassium and renal function, and consider an alternative to amiloride or a dose reduction if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Amiloride with Erdafitinib?
MediHelp rates the interaction as moderate. Amiloride and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits the renal transporter OCT2, which contributes to the tubular secretion of amiloride. This may increase amiloride exposure and the risk of dose-related adverse effects such as hyperkalemia.
How serious is the interaction between Amiloride and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, and consider an alternative to amiloride or a dose reduction if hyperkalemia develops.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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