Drug interactions
Amiloride + Flurbiprofen
Severity: Major
Amiloride and Flurbiprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride is a potassium-sparing diuretic, and NSAIDs reduce renal potassium excretion and can impair renal function. Together they can cause clinically important hyperkalemia and acute kidney injury, and NSAIDs may also blunt the diuretic and antihypertensive effect.
What this interaction means in plain words
Amiloride and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Amiloride blocks distal sodium channels reducing potassium excretion, while NSAIDs suppress renin-aldosterone via prostaglandin inhibition and lower GFR.
What to do
Avoid the combination where possible, particularly in older patients or those with renal impairment or diabetes. If used, check serum potassium and creatinine early and periodically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Flurbiprofen?
MediHelp rates the interaction as major. Amiloride and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiloride is a potassium-sparing diuretic, and NSAIDs reduce renal potassium excretion and can impair renal function. Together they can cause clinically important hyperkalemia and acute kidney injury, and NSAIDs may also blunt the diuretic and antihypertensive effect.
How serious is the interaction between Amiloride and Flurbiprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in older patients or those with renal impairment or diabetes. If used, check serum potassium and creatinine early and periodically.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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