Drug interactions
Flurbiprofen + Ketorolac intranasal
Severity: Contraindicated
Flurbiprofen and Ketorolac intranasal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is contraindicated with other NSAIDs because the combination increases the risk of gastrointestinal bleeding, perforation and renal impairment. Intranasal ketorolac is systemically absorbed, so the warning applies.
What this interaction means in plain words
Flurbiprofen and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cyclooxygenase inhibition causing GI mucosal injury, platelet inhibition and reduced renal prostaglandins.
What to do
Do not use together. Use one NSAID at a time and choose a non-NSAID analgesic such as paracetamol if more analgesia is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
- Amiloride + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Ketorolac intranasal?
MediHelp rates the interaction as contraindicated. Flurbiprofen and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac is contraindicated with other NSAIDs because the combination increases the risk of gastrointestinal bleeding, perforation and renal impairment. Intranasal ketorolac is systemically absorbed, so the warning applies.
How serious is the interaction between Flurbiprofen and Ketorolac intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use one NSAID at a time and choose a non-NSAID analgesic such as paracetamol if more analgesia is needed.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Flurbiprofen page.
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