Drug interactions
Amiloride + Fluticasone-salmeterol
Severity: Minor
Amiloride and Fluticasone-salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol can lower serum potassium while amiloride retains it. The opposing actions make the net effect unpredictable and usually small. Hyperkalemia risk from amiloride remains the greater concern in renal impairment.
What this interaction means in plain words
Amiloride and Fluticasone-salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Opposing effects on potassium: beta2-mediated cellular uptake versus inhibition of renal potassium secretion by amiloride.
What to do
No routine change is needed; monitor serum potassium in patients with renal impairment or on other potassium-altering drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Fluticasone-salmeterol?
MediHelp rates the interaction as minor. Amiloride and Fluticasone-salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salmeterol can lower serum potassium while amiloride retains it. The opposing actions make the net effect unpredictable and usually small. Hyperkalemia risk from amiloride remains the greater concern in renal impairment.
How serious is the interaction between Amiloride and Fluticasone-salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor serum potassium in patients with renal impairment or on other potassium-altering drugs.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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