Drug interactions
Fluticasone-salmeterol + Nelfinavir
Severity: Contraindicated
Fluticasone-salmeterol and Nelfinavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can raise salmeterol concentrations, increasing the risk of QT prolongation, palpitations and arrhythmias. Fluticasone exposure may also increase, causing systemic corticosteroid effects.
What this interaction means in plain words
Fluticasone-salmeterol and Nelfinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluticasone-salmeterol belongs to Respiratory; Nelfinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition decreases the metabolic clearance of salmeterol and fluticasone.
What to do
Avoid concurrent use and select an inhaled regimen that does not rely on CYP3A4. If it cannot be avoided, monitor ECG and potassium and watch for corticosteroid excess.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Ritonavir Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Nelfinavir?
MediHelp rates the interaction as contraindicated. Fluticasone-salmeterol and Nelfinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nelfinavir inhibits CYP3A4 and can raise salmeterol concentrations, increasing the risk of QT prolongation, palpitations and arrhythmias. Fluticasone exposure may also increase, causing systemic corticosteroid effects.
How serious is the interaction between Fluticasone-salmeterol and Nelfinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select an inhaled regimen that does not rely on CYP3A4. If it cannot be avoided, monitor ECG and potassium and watch for corticosteroid excess.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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