Drug interactions
Amiloride + Sulphasalazine
Severity: Minor
Amiloride and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride is a potassium-sparing diuretic that commonly causes hyperkalemia. Sulfasalazine has no established direct effect on potassium, so a meaningful interaction is not clearly supported.
What this interaction means in plain words
Amiloride and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; hyperkalemia risk comes mainly from amiloride, with sulfasalazine contributing at most rarely via renal effects.
What to do
Monitor serum potassium and renal function as for any amiloride therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Sulphasalazine?
MediHelp rates the interaction as minor. Amiloride and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiloride is a potassium-sparing diuretic that commonly causes hyperkalemia. Sulfasalazine has no established direct effect on potassium, so a meaningful interaction is not clearly supported.
How serious is the interaction between Amiloride and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function as for any amiloride therapy.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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