Drug reference
sulphasalazine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Gastrointestinal Tract (Azo Compounds)
Mechanism of action
Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase.
Common side effects
- Anorexia
- Headache
- Nausea, Vomiting
- Gastric distress
- Apparently reversible oligospermia
Contraindications
- Hypersensitivity to sulfasalazine or its metabolites, to sulfonamides, or to salicylates Intestinal or urinary tract obstruction Porphyria
Related conditions
Frequently asked questions
What drug class is sulphasalazine?
sulphasalazine belongs to: Gastrointestinal Tract.
How does sulphasalazine work?
Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase.
What are the common side effects of sulphasalazine?
Anorexia, Headache, Nausea, Vomiting, Gastric distress, Apparently reversible oligospermia
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