Drug interactions
Amiloride + Tadalafil
Severity: Minor
Amiloride and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil's vasodilating effect may add to the blood pressure reduction from amiloride, a potassium-sparing diuretic. Clinically important hypotension is uncommon but possible with volume depletion.
What this interaction means in plain words
Amiloride and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic blood pressure lowering from PDE5 inhibition and diuretic effect.
What to do
No dose change is usually needed; monitor blood pressure and ask about dizziness when starting tadalafil.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Tadalafil?
MediHelp rates the interaction as minor. Amiloride and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil's vasodilating effect may add to the blood pressure reduction from amiloride, a potassium-sparing diuretic. Clinically important hypotension is uncommon but possible with volume depletion.
How serious is the interaction between Amiloride and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood pressure and ask about dizziness when starting tadalafil.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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