Drug interactions
Amiloride + Timolol
Severity: Moderate
Amiloride and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride retains potassium and systemically absorbed timolol, a non-selective beta-blocker, may reduce cellular potassium uptake. Hyperkalemia is possible, particularly in patients with kidney disease.
What this interaction means in plain words
Amiloride and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Reduced renal potassium excretion from amiloride plus impaired beta-2-mediated potassium uptake into cells.
What to do
Monitor serum potassium and renal function periodically. Reduce or stop amiloride if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Amiloride with Timolol?
MediHelp rates the interaction as moderate. Amiloride and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiloride retains potassium and systemically absorbed timolol, a non-selective beta-blocker, may reduce cellular potassium uptake. Hyperkalemia is possible, particularly in patients with kidney disease.
How serious is the interaction between Amiloride and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function periodically. Reduce or stop amiloride if potassium rises.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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