Drug interactions
Amiloride + Tolmetin
Severity: Moderate
Amiloride and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the renal effects of potassium-sparing diuretics and raise serum potassium. Hyperkalemia and acute kidney injury are more likely in older patients or those with renal impairment or diabetes.
What this interaction means in plain words
Amiloride and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAIDs suppress prostaglandin-mediated renin and aldosterone release and reduce renal blood flow, impairing potassium excretion that is further reduced by amiloride.
What to do
Check serum potassium and creatinine within the first weeks and periodically thereafter. Avoid in patients with renal impairment or other hyperkalemia risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Tolmetin?
MediHelp rates the interaction as moderate. Amiloride and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the renal effects of potassium-sparing diuretics and raise serum potassium. Hyperkalemia and acute kidney injury are more likely in older patients or those with renal impairment or diabetes.
How serious is the interaction between Amiloride and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine within the first weeks and periodically thereafter. Avoid in patients with renal impairment or other hyperkalemia risks.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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