Drug interactions
Amiloride + Vandetanib
Severity: Moderate
Amiloride and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits the renal organic cation transporter OCT2, which is involved in tubular secretion of amiloride. Amiloride exposure may therefore rise, increasing the risk of hyperkalemia. Vandetanib also prolongs the QT interval, and electrolyte disturbances worsen that risk.
What this interaction means in plain words
Amiloride and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Vandetanib belongs to Oncology.
Why it happens
Vandetanib inhibits OCT2-mediated renal tubular secretion of amiloride, reducing its clearance.
What to do
Monitor serum potassium and ECG/QTc regularly during co-therapy. Correct potassium abnormalities promptly and reduce amiloride dose if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Amiloride with Vandetanib?
MediHelp rates the interaction as moderate. Amiloride and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits the renal organic cation transporter OCT2, which is involved in tubular secretion of amiloride. Amiloride exposure may therefore rise, increasing the risk of hyperkalemia. Vandetanib also prolongs the QT interval, and electrolyte disturbances worsen that risk.
How serious is the interaction between Amiloride and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG/QTc regularly during co-therapy. Correct potassium abnormalities promptly and reduce amiloride dose if hyperkalemia develops.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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