Drug interactions
Amisulpride + Vandetanib
Severity: Contraindicated
Amisulpride and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib has a boxed warning for QT prolongation, torsades de pointes, and sudden death, and its use with other QT-prolonging drugs is to be avoided. Amisulpride would add to this risk.
What this interaction means in plain words
Amisulpride and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amisulpride belongs to Central Nervous System; Vandetanib belongs to Oncology.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Do not combine; use a non-QT-prolonging alternative to amisulpride. If vandetanib treatment is essential, stop amisulpride.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
- Chlorpromazine + Vandetanib Contraindicated
Frequently asked questions
Can I take Amisulpride with Vandetanib?
MediHelp rates the interaction as contraindicated. Amisulpride and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib has a boxed warning for QT prolongation, torsades de pointes, and sudden death, and its use with other QT-prolonging drugs is to be avoided. Amisulpride would add to this risk.
How serious is the interaction between Amisulpride and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a non-QT-prolonging alternative to amisulpride. If vandetanib treatment is essential, stop amisulpride.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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