Drug interactions
Aminohippurate + Chlorthalidone
Severity: Minor
Aminohippurate and Chlorthalidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone is secreted by organic anion transporters in the proximal tubule and may compete with aminohippurate. This could alter the renal plasma flow measurement, though aminohippurate is only used diagnostically.
What this interaction means in plain words
Aminohippurate and Chlorthalidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporter-mediated renal tubular secretion.
What to do
Consider withholding chlorthalidone before renal plasma flow testing, or interpret results with the diuretic in mind.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Aminohippurate with Chlorthalidone?
MediHelp rates the interaction as minor. Aminohippurate and Chlorthalidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorthalidone is secreted by organic anion transporters in the proximal tubule and may compete with aminohippurate. This could alter the renal plasma flow measurement, though aminohippurate is only used diagnostically.
How serious is the interaction between Aminohippurate and Chlorthalidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding chlorthalidone before renal plasma flow testing, or interpret results with the diuretic in mind.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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