Drug interactions
Aminohippurate + Flurbiprofen
Severity: Minor
Aminohippurate and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminohippurate is used as a diagnostic agent to measure renal plasma flow and is secreted by organic anion transporters in the proximal tubule. NSAIDs such as flurbiprofen can compete for this secretion and may lead to underestimation of renal plasma flow.
What this interaction means in plain words
Aminohippurate and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transporters.
What to do
Where possible, withhold the NSAID before renal plasma flow testing, or interpret results with the NSAID in mind.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Aminohippurate with Flurbiprofen?
MediHelp rates the interaction as minor. Aminohippurate and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminohippurate is used as a diagnostic agent to measure renal plasma flow and is secreted by organic anion transporters in the proximal tubule. NSAIDs such as flurbiprofen can compete for this secretion and may lead to underestimation of renal plasma flow.
How serious is the interaction between Aminohippurate and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, withhold the NSAID before renal plasma flow testing, or interpret results with the NSAID in mind.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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