Drug interactions
Aminohippurate + Hydrochlorothiazide-valsartan
Severity: Minor
Aminohippurate and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is secreted by organic anion transporters in the proximal tubule and may compete with aminohippurate. This can reduce aminohippurate clearance and may distort renal plasma flow measurements.
What this interaction means in plain words
Aminohippurate and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion.
What to do
If aminohippurate is used to estimate renal plasma flow, account for thiazide use when interpreting results or consider withholding the diuretic per the testing protocol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Aminohippurate with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Aminohippurate and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is secreted by organic anion transporters in the proximal tubule and may compete with aminohippurate. This can reduce aminohippurate clearance and may distort renal plasma flow measurements.
How serious is the interaction between Aminohippurate and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If aminohippurate is used to estimate renal plasma flow, account for thiazide use when interpreting results or consider withholding the diuretic per the testing protocol.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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