Drug reference
hydrochlorothiazide-valsartan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Valsartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors; blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II. Hydrochlorothiazide: Thiazide diuretic that inhibits sodium reabsorption in distal renal tubules; results in increased excretion of sodium ions and water, as well as potassium and hydrogen ions
Common side effects
- Anorexia
- Anemia
- Dizziness
- Fatigue
- Anaphylaxis
- Hyperkalemia
- Hypotension
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to valsartan, hydrochlorothiazide, or sulfonamides Anuria Coadministration with aliskiren in patients with diabetes
Known interactions (1)
Related conditions
Frequently asked questions
What drug class is hydrochlorothiazide-valsartan?
hydrochlorothiazide-valsartan belongs to: Cardiovascular.
How does hydrochlorothiazide-valsartan work?
Valsartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors; blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II. Hydrochlorothiazide: Thiazide diuretic that inhibits sodium reabsorption in distal renal tubules; results in increased excretion of sodium ions and water, as well as potassium and hydrogen ions
What are the common side effects of hydrochlorothiazide-valsartan?
Anorexia, Anemia, Dizziness, Fatigue, Anaphylaxis, Hyperkalemia, Hypotension
Which drugs interact with hydrochlorothiazide-valsartan?
isocarboxazid
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.