Drug interactions
Aminohippurate + Ibuprofen
Severity: Minor
Aminohippurate and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are organic anions secreted by renal tubular transporters, so ibuprofen may compete with aminohippurate and reduce its secretion. This could lead to underestimation of effective renal plasma flow when aminohippurate clearance is used as a diagnostic measure.
What this interaction means in plain words
Aminohippurate and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal organic anion transporters (OAT) mediating tubular secretion.
What to do
Be aware of the potential for altered test results; consider withholding ibuprofen before renal plasma flow testing if feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Aminohippurate with Ibuprofen?
MediHelp rates the interaction as minor. Aminohippurate and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are organic anions secreted by renal tubular transporters, so ibuprofen may compete with aminohippurate and reduce its secretion. This could lead to underestimation of effective renal plasma flow when aminohippurate clearance is used as a diagnostic measure.
How serious is the interaction between Aminohippurate and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of the potential for altered test results; consider withholding ibuprofen before renal plasma flow testing if feasible.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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