Drug interactions
Aminohippurate + Tolmetin
Severity: Minor
Aminohippurate and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are organic anions secreted by renal tubular transporters, so tolmetin may compete with aminohippurate for secretion. This could alter renal plasma flow measurements that depend on aminohippurate clearance.
What this interaction means in plain words
Aminohippurate and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporter-mediated tubular secretion.
What to do
Consider interpreting renal plasma flow results with care, or hold the NSAID before testing if practical.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aminohippurate and Tolmetin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Aminohippurate with Tolmetin?
MediHelp rates the interaction as minor. Aminohippurate and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are organic anions secreted by renal tubular transporters, so tolmetin may compete with aminohippurate for secretion. This could alter renal plasma flow measurements that depend on aminohippurate clearance.
How serious is the interaction between Aminohippurate and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider interpreting renal plasma flow results with care, or hold the NSAID before testing if practical.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
