Drug interactions
Amitriptyline + Arformoterol
Severity: Moderate
Amitriptyline and Arformoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of long-acting beta-agonists such as arformoterol. This can cause tachycardia, palpitations, QT prolongation and arrhythmias. Labeling recommends caution with tricyclics.
What this interaction means in plain words
Amitriptyline and Arformoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Arformoterol belongs to Respiratory.
Why it happens
Tricyclics inhibit norepinephrine reuptake and may enhance cardiac and vascular beta-agonist effects, with additive QT effects.
What to do
Monitor heart rate, blood pressure and ECG in at-risk patients, and watch for palpitations. Consider an alternative bronchodilator if cardiovascular effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Amitriptyline with Arformoterol?
MediHelp rates the interaction as moderate. Amitriptyline and Arformoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of long-acting beta-agonists such as arformoterol. This can cause tachycardia, palpitations, QT prolongation and arrhythmias. Labeling recommends caution with tricyclics.
How serious is the interaction between Amitriptyline and Arformoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in at-risk patients, and watch for palpitations. Consider an alternative bronchodilator if cardiovascular effects occur.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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