Drug interactions
Amitriptyline + Atracurium
Severity: Minor
Amitriptyline and Atracurium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline has anticholinergic properties but no established meaningful effect on the action of non-depolarizing neuromuscular blockers. Any clinical interaction with atracurium is theoretical and not well documented.
What this interaction means in plain words
Amitriptyline and Atracurium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Atracurium belongs to Musculoskeletal.
Why it happens
No established mechanism; the proposed pharmacodynamic link is not supported by clear evidence.
What to do
No dose adjustment is needed; use routine neuromuscular monitoring during anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atracurium
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Atracurium?
MediHelp rates the interaction as minor. Amitriptyline and Atracurium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amitriptyline has anticholinergic properties but no established meaningful effect on the action of non-depolarizing neuromuscular blockers. Any clinical interaction with atracurium is theoretical and not well documented.
How serious is the interaction between Amitriptyline and Atracurium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; use routine neuromuscular monitoring during anesthesia.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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