Drug interactions
Amitriptyline + Bazedoxifene / conjugated estrogens
Severity: Minor
Amitriptyline and Bazedoxifene / conjugated estrogens: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may change tricyclic antidepressant exposure, with reports of higher antidepressant levels and increased adverse effects in some patients. The effect is variable and usually modest.
What this interaction means in plain words
Amitriptyline and Bazedoxifene / conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible estrogen-related inhibition of hepatic tricyclic metabolism; the mechanism is not firmly established.
What to do
Monitor antidepressant response and anticholinergic or sedative adverse effects when starting or stopping estrogen. Adjust the amitriptyline dose if toxicity or loss of effect emerges.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Bazedoxifene / conjugated estrogens?
MediHelp rates the interaction as minor. Amitriptyline and Bazedoxifene / conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may change tricyclic antidepressant exposure, with reports of higher antidepressant levels and increased adverse effects in some patients. The effect is variable and usually modest.
How serious is the interaction between Amitriptyline and Bazedoxifene / conjugated estrogens?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and anticholinergic or sedative adverse effects when starting or stopping estrogen. Adjust the amitriptyline dose if toxicity or loss of effect emerges.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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