Drug interactions
Amitriptyline + Benperidol
Severity: Moderate
Amitriptyline and Benperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and each can affect cardiac conduction and QT interval. Combined use may increase drowsiness, hypotension, and the potential for ventricular arrhythmia.
What this interaction means in plain words
Amitriptyline and Benperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, hypotensive and QT-prolonging effects.
What to do
Monitor sedation and orthostatic blood pressure, and obtain an ECG in patients with cardiac risk factors. Keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Benperidol?
MediHelp rates the interaction as moderate. Amitriptyline and Benperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and each can affect cardiac conduction and QT interval. Combined use may increase drowsiness, hypotension, and the potential for ventricular arrhythmia.
How serious is the interaction between Amitriptyline and Benperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, and obtain an ECG in patients with cardiac risk factors. Keep potassium and magnesium within normal range.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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