Drug interactions
Amitriptyline + Benzphetamine
Severity: Moderate
Amitriptyline and Benzphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can alter the response to sympathomimetic amines like benzphetamine, with possible hypertension, tachycardia or arrhythmia. The effect may vary depending on whether uptake into the neuron is blocked. Risk is higher in patients with cardiovascular disease.
What this interaction means in plain words
Amitriptyline and Benzphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics block norepinephrine reuptake and uptake of indirect sympathomimetics, changing adrenergic responses.
What to do
Monitor blood pressure and heart rate, and avoid the combination in patients with hypertension or heart disease. Consider a different weight-loss approach.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Benzphetamine?
MediHelp rates the interaction as moderate. Amitriptyline and Benzphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can alter the response to sympathomimetic amines like benzphetamine, with possible hypertension, tachycardia or arrhythmia. The effect may vary depending on whether uptake into the neuron is blocked. Risk is higher in patients with cardiovascular disease.
How serious is the interaction between Amitriptyline and Benzphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and avoid the combination in patients with hypertension or heart disease. Consider a different weight-loss approach.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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