Drug interactions
Amitriptyline + Buprenorphine buccal
Severity: Major
Amitriptyline and Buprenorphine buccal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, and buprenorphine adds CNS depression to amitriptyline sedation. This raises the risk of arrhythmia and respiratory depression. Serotonergic effects are also possible.
What this interaction means in plain words
Amitriptyline and Buprenorphine buccal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and additive CNS depression, with possible serotonergic effects.
What to do
Use only if alternatives are inadequate, with the lowest effective doses. Obtain an ECG in patients with risk factors and monitor sedation and respiration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Buprenorphine buccal?
MediHelp rates the interaction as major. Amitriptyline and Buprenorphine buccal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, and buprenorphine adds CNS depression to amitriptyline sedation. This raises the risk of arrhythmia and respiratory depression. Serotonergic effects are also possible.
How serious is the interaction between Amitriptyline and Buprenorphine buccal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if alternatives are inadequate, with the lowest effective doses. Obtain an ECG in patients with risk factors and monitor sedation and respiration.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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