Drug interactions
Amitriptyline + Clemastine
Severity: Moderate
Amitriptyline and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating and anticholinergic, so combining them can cause marked drowsiness, dry mouth, constipation, urinary retention and confusion. Older patients are at highest risk.
What this interaction means in plain words
Amitriptyline and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Clemastine belongs to Respiratory.
Why it happens
Additive H1-receptor antagonism, CNS depression and muscarinic blockade.
What to do
Avoid the combination in elderly patients and consider a non-sedating antihistamine. Counsel about drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Amitriptyline with Clemastine?
MediHelp rates the interaction as moderate. Amitriptyline and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating and anticholinergic, so combining them can cause marked drowsiness, dry mouth, constipation, urinary retention and confusion. Older patients are at highest risk.
How serious is the interaction between Amitriptyline and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in elderly patients and consider a non-sedating antihistamine. Counsel about drowsiness and driving.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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