Drug interactions
Amitriptyline + Dipipanone
Severity: Moderate
Amitriptyline and Dipipanone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is an opioid analgesic, and combining it with a tricyclic antidepressant increases sedation and may cause respiratory depression. Amitriptyline may also add to opioid-related constipation and urinary retention.
What this interaction means in plain words
Amitriptyline and Dipipanone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid receptor agonism and amitriptyline sedative and anticholinergic effects.
What to do
Start with low opioid doses and titrate slowly, monitoring sedation and respiratory rate. Counsel patients to avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amitriptyline and Dipipanone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Dipipanone?
MediHelp rates the interaction as moderate. Amitriptyline and Dipipanone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipipanone is an opioid analgesic, and combining it with a tricyclic antidepressant increases sedation and may cause respiratory depression. Amitriptyline may also add to opioid-related constipation and urinary retention.
How serious is the interaction between Amitriptyline and Dipipanone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low opioid doses and titrate slowly, monitoring sedation and respiratory rate. Counsel patients to avoid alcohol and other sedatives.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
