Drug interactions
Amitriptyline + Echothiophate iodide
Severity: Minor
Amitriptyline and Echothiophate iodide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Echothiophate is an ophthalmic cholinesterase inhibitor, and amitriptyline has antimuscarinic activity that may partly oppose it. Systemic absorption of the eye drops is limited, so any interaction is likely to be small. Echothiophate can also cause systemic cholinergic effects that might be blunted.
What this interaction means in plain words
Amitriptyline and Echothiophate iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic opposition between cholinesterase inhibition and muscarinic receptor blockade.
What to do
Monitor intraocular pressure and the pupillary response to echothiophate. Adjust the ophthalmic regimen if the effect is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Echothiophate iodide?
MediHelp rates the interaction as minor. Amitriptyline and Echothiophate iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Echothiophate is an ophthalmic cholinesterase inhibitor, and amitriptyline has antimuscarinic activity that may partly oppose it. Systemic absorption of the eye drops is limited, so any interaction is likely to be small. Echothiophate can also cause systemic cholinergic effects that might be blunted.
How serious is the interaction between Amitriptyline and Echothiophate iodide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor intraocular pressure and the pupillary response to echothiophate. Adjust the ophthalmic regimen if the effect is reduced.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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