Drug interactions
Amitriptyline + Esketamine intranasal
Severity: Moderate
Amitriptyline and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, so combined use may intensify CNS depression and impair attention and driving ability. Esketamine can also raise blood pressure, and amitriptyline may add to cardiovascular effects.
What this interaction means in plain words
Amitriptyline and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects and additive pressor or cardiovascular effects.
What to do
Monitor sedation and blood pressure during and after esketamine administration, as required by the product's monitoring protocol. Advise patients not to drive until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Esketamine intranasal?
MediHelp rates the interaction as moderate. Amitriptyline and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dizziness, so combined use may intensify CNS depression and impair attention and driving ability. Esketamine can also raise blood pressure, and amitriptyline may add to cardiovascular effects.
How serious is the interaction between Amitriptyline and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during and after esketamine administration, as required by the product's monitoring protocol. Advise patients not to drive until the next day after a restful sleep.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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