Drug interactions
Amitriptyline + Esketamine
Severity: Moderate
Amitriptyline and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline is sedating and anticholinergic, and esketamine causes sedation, dissociation and transient blood pressure rises. Combined use may increase drowsiness and impair psychomotor performance.
What this interaction means in plain words
Amitriptyline and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression through different receptor mechanisms.
What to do
Monitor sedation and blood pressure during and after each esketamine session. Advise patients not to drive until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Esketamine?
MediHelp rates the interaction as moderate. Amitriptyline and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline is sedating and anticholinergic, and esketamine causes sedation, dissociation and transient blood pressure rises. Combined use may increase drowsiness and impair psychomotor performance.
How serious is the interaction between Amitriptyline and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during and after each esketamine session. Advise patients not to drive until the next day after a restful sleep.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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