Drug interactions
Amitriptyline + Glecaprevir / pibrentasvir
Severity: Minor
Amitriptyline and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and other transporters, which could increase exposure to amitriptyline. The clinical effect is probably modest, since amitriptyline relies mainly on CYP metabolism.
What this interaction means in plain words
Amitriptyline and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-glycoprotein efflux may increase amitriptyline absorption and exposure.
What to do
Monitor for increased tricyclic adverse effects such as sedation, anticholinergic symptoms and palpitations. Reduce the amitriptyline dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Amitriptyline and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein and other transporters, which could increase exposure to amitriptyline. The clinical effect is probably modest, since amitriptyline relies mainly on CYP metabolism.
How serious is the interaction between Amitriptyline and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased tricyclic adverse effects such as sedation, anticholinergic symptoms and palpitations. Reduce the amitriptyline dose if toxicity occurs.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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