Drug interactions
Amitriptyline + Henbane
Severity: Moderate
Amitriptyline and Henbane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains anticholinergic alkaloids such as hyoscyamine and scopolamine, and amitriptyline has strong anticholinergic activity. Together they can cause dry mouth, urinary retention, constipation, blurred vision, confusion and tachycardia.
What this interaction means in plain words
Amitriptyline and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Avoid the combination in older adults and those with glaucoma, urinary retention or cognitive impairment. Monitor for anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Henbane?
MediHelp rates the interaction as moderate. Amitriptyline and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains anticholinergic alkaloids such as hyoscyamine and scopolamine, and amitriptyline has strong anticholinergic activity. Together they can cause dry mouth, urinary retention, constipation, blurred vision, confusion and tachycardia.
How serious is the interaction between Amitriptyline and Henbane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older adults and those with glaucoma, urinary retention or cognitive impairment. Monitor for anticholinergic toxicity.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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