Drug interactions
Amitriptyline + Indacaterol inhaled
Severity: Moderate
Amitriptyline and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and beta-2 agonists can also cause hypokalemia and tachycardia. Together they may increase the risk of ventricular arrhythmias, especially in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Amitriptyline and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and adrenergic cardiac stimulation; tricyclics also potentiate cardiovascular effects of beta-agonists.
What to do
Check baseline ECG and potassium and magnesium in patients with cardiac risk factors, and monitor for palpitations or arrhythmia. Consider an alternative if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Amitriptyline and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and beta-2 agonists can also cause hypokalemia and tachycardia. Together they may increase the risk of ventricular arrhythmias, especially in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Amitriptyline and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and potassium and magnesium in patients with cardiac risk factors, and monitor for palpitations or arrhythmia. Consider an alternative if QTc is prolonged.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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