Drug interactions
Amitriptyline + Loprazolam
Severity: Moderate
Amitriptyline and Loprazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline and loprazolam both cause sedation, and combined use can increase drowsiness, impaired coordination and cognitive slowing. Falls and accidents are a concern, particularly in older adults.
What this interaction means in plain words
Amitriptyline and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from sedating tricyclic and benzodiazepine activity.
What to do
Use the lowest effective doses and the shortest duration, and warn patients about driving and alcohol. Monitor older patients for falls and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Loprazolam?
MediHelp rates the interaction as moderate. Amitriptyline and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline and loprazolam both cause sedation, and combined use can increase drowsiness, impaired coordination and cognitive slowing. Falls and accidents are a concern, particularly in older adults.
How serious is the interaction between Amitriptyline and Loprazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and the shortest duration, and warn patients about driving and alcohol. Monitor older patients for falls and confusion.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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