Drug interactions
Amitriptyline + Lsd
Severity: Moderate
Amitriptyline and Lsd: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD acts as a serotonin receptor agonist, and amitriptyline increases synaptic serotonin, so combined use may cause serotonergic toxicity. Tricyclics have also been reported to alter LSD effects unpredictably, and LSD is an illicit substance.
What this interaction means in plain words
Amitriptyline and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity from 5-HT receptor agonism and inhibition of serotonin reuptake.
What to do
Counsel patients to avoid LSD while taking amitriptyline. If exposure occurs, monitor for agitation, hyperthermia, tachycardia and neuromuscular signs and give supportive care.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Lsd?
MediHelp rates the interaction as moderate. Amitriptyline and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD acts as a serotonin receptor agonist, and amitriptyline increases synaptic serotonin, so combined use may cause serotonergic toxicity. Tricyclics have also been reported to alter LSD effects unpredictably, and LSD is an illicit substance.
How serious is the interaction between Amitriptyline and Lsd?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid LSD while taking amitriptyline. If exposure occurs, monitor for agitation, hyperthermia, tachycardia and neuromuscular signs and give supportive care.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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