Drug interactions
Amitriptyline + Marijuana
Severity: Moderate
Amitriptyline and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can add to the sedation and impairment caused by amitriptyline, and both can cause tachycardia. Reports describe confusion, tachycardia and in some cases delirium when combined.
What this interaction means in plain words
Amitriptyline and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic/sympathomimetic cardiovascular effects; cannabinoids may also affect CYP metabolism.
What to do
Advise patients to avoid or minimize cannabis use and avoid driving. Monitor heart rate and mental status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Marijuana?
MediHelp rates the interaction as moderate. Amitriptyline and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can add to the sedation and impairment caused by amitriptyline, and both can cause tachycardia. Reports describe confusion, tachycardia and in some cases delirium when combined.
How serious is the interaction between Amitriptyline and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid or minimize cannabis use and avoid driving. Monitor heart rate and mental status.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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