Drug interactions
Amitriptyline + Metformin
Severity: Minor
Amitriptyline and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline may alter glycemic control in patients with diabetes, sometimes lowering glucose and sometimes raising it. The clinical effect with metformin is generally small, and metformin alone rarely causes hypoglycemia.
What this interaction means in plain words
Amitriptyline and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Metformin belongs to Endocrine.
Why it happens
Possible additive pharmacodynamic effect on glucose; no established pharmacokinetic mechanism.
What to do
Check glycemic control after starting or stopping amitriptyline. No routine dose change of metformin is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Metformin
Frequently asked questions
Can I take Amitriptyline with Metformin?
MediHelp rates the interaction as minor. Amitriptyline and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amitriptyline may alter glycemic control in patients with diabetes, sometimes lowering glucose and sometimes raising it. The clinical effect with metformin is generally small, and metformin alone rarely causes hypoglycemia.
How serious is the interaction between Amitriptyline and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glycemic control after starting or stopping amitriptyline. No routine dose change of metformin is needed.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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