Drug interactions
Amitriptyline + Metoclopramide intranasal
Severity: Moderate
Amitriptyline and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause extrapyramidal effects and tardive dyskinesia, and amitriptyline may add to dopaminergic and anticholinergic disturbances. Both can also contribute to sedation and, rarely, serotonin syndrome or neuroleptic malignant syndrome. Amitriptyline also inhibits CYP2D6, which metabolises metoclopramide.
What this interaction means in plain words
Amitriptyline and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and extrapyramidal effects, with possible CYP2D6 inhibition by amitriptyline raising metoclopramide exposure.
What to do
Monitor for extrapyramidal symptoms, sedation and signs of serotonin toxicity. Use the lowest effective metoclopramide dose and stop it if movement disorders emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Amitriptyline and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause extrapyramidal effects and tardive dyskinesia, and amitriptyline may add to dopaminergic and anticholinergic disturbances. Both can also contribute to sedation and, rarely, serotonin syndrome or neuroleptic malignant syndrome. Amitriptyline also inhibits CYP2D6, which metabolises metoclopramide.
How serious is the interaction between Amitriptyline and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and signs of serotonin toxicity. Use the lowest effective metoclopramide dose and stop it if movement disorders emerge.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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