Drug interactions
Amitriptyline + Mobocertinib
Severity: Major
Amitriptyline and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib prolongs the QT interval and amitriptyline has QT-prolonging potential, so the combination raises the risk of torsades de pointes. The legacy mechanism of enzyme induction is not accurate for this pair, since the concern is mainly additive cardiac toxicity.
What this interaction means in plain words
Amitriptyline and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation; mobocertinib is also a CYP3A substrate and weak inducer, with uncertain effect on amitriptyline levels.
What to do
Avoid the combination if possible. If it is required, monitor the ECG and electrolytes frequently and reduce or interrupt mobocertinib for QTc prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Mobocertinib?
MediHelp rates the interaction as major. Amitriptyline and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib prolongs the QT interval and amitriptyline has QT-prolonging potential, so the combination raises the risk of torsades de pointes. The legacy mechanism of enzyme induction is not accurate for this pair, since the concern is mainly additive cardiac toxicity.
How serious is the interaction between Amitriptyline and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is required, monitor the ECG and electrolytes frequently and reduce or interrupt mobocertinib for QTc prolongation.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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