Drug interactions
Amitriptyline + Motherwort
Severity: Minor
Amitriptyline and Motherwort: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Motherwort is used traditionally as a mild sedative and may add to the drowsiness caused by amitriptyline. Impaired alertness and psychomotor performance are possible.
What this interaction means in plain words
Amitriptyline and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects; the herbal constituents are poorly characterized.
What to do
Advise patients to watch for excessive drowsiness and avoid driving if affected. Consider stopping the herbal product if sedation becomes troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amitriptyline and Motherwort, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Motherwort?
MediHelp rates the interaction as minor. Amitriptyline and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Motherwort is used traditionally as a mild sedative and may add to the drowsiness caused by amitriptyline. Impaired alertness and psychomotor performance are possible.
How serious is the interaction between Amitriptyline and Motherwort?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for excessive drowsiness and avoid driving if affected. Consider stopping the herbal product if sedation becomes troublesome.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
