Drug interactions
Amitriptyline + Octreotide
Severity: Moderate
Amitriptyline and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and amitriptyline can prolong the QT interval too, so the combination may add arrhythmic risk. The effect is generally modest, and clinical reports are limited.
What this interaction means in plain words
Amitriptyline and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia increasing susceptibility.
What to do
Check a baseline ECG and electrolytes in patients with other QT risk factors or bradycardia, and monitor heart rate and QTc during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Amitriptyline with Octreotide?
MediHelp rates the interaction as moderate. Amitriptyline and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and amitriptyline can prolong the QT interval too, so the combination may add arrhythmic risk. The effect is generally modest, and clinical reports are limited.
How serious is the interaction between Amitriptyline and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes in patients with other QT risk factors or bradycardia, and monitor heart rate and QTc during therapy.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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